Open up left-most blanks first: Always look first for a play that opens up a left-most position so you can play a 2 in it.

Play to extend sequence: Then look for plays that allow you to extend an existing sequence. This is best done by looking at the first card out-of-sequence in a row. Figure out where that plays. Then figure out where the card there plays. Follow the chain until you get to a blank space which allows you to make all the plays.

Do not make unnecessary plays: Play to open up blank spaces to the right of cards in sequence. But do not play the next card in sequence right away. Keep looking to extend the number of blanks where you can plays cards in sequence.

Extend sequences: When you cannot make any more blank plays, extend the sequences where you can.

Random plays: If nothing else looks good just make a few random plays to change the layout of the cards. Then starts looking for plays that open up useful blank places again.